Aged 18-70 years

CLBP in the area L1 to S1 associated with vertebral body endplate bone oedema (Modic 1) or vertebral body endplate bone oedema and fat (Modic 1 and 2), at a single lumbar level

CLBP has lasted > 6 months

Moderate-severe pain, back pain greater than leg pain

Moderate-severe disability

There is no clear alternative cause for back pain

Failure of standard of care therapies

The target lumbar disc must not have lost more than half its anticipated height at its centre

Further information can be found at clinicaltrials.gov